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["Pneumococcal conjugate vaccine choice: "]
["Cost comparison model"]
["User guide"]
["For questions or support, contact PATH's Health Economics & Outcomes Research team: HEOR@path.org"]
["Version 1.0"]
["The Pneumococcal conjugate vaccine choice: Cost comparison model is a simple tool for assessing and comparing costs of PCV vaccination programs with each PCV product available in the global market. It aims to help country-level policy-makers compare products and estimate vaccination program costs for different PCV vaccines, exploring up to six different vaccine options at a time. The tool can be used by any country interested in comparing different PCV vaccine costs, whether or not the country is eligible for co-funding from Gavi, the Vaccine Alliance. "]
[]
["The tool calculates costs annually and for a total period of 10 years. Estimates of vaccine cost (i.e., vaccine and supplies procurement and international shipping) and vaccination program costs (i.e., vaccine cost and cost of delivery) are provided separately for two perspectives: (1) the country perspective and (2) the combined country and Gavi perspective (only relevant for Gavi-eligible countries). The country perspective accounts only for what is paid from the country budget, while the country and Gavi perspective also accounts for Gavi co-financing of vaccines and support grants. All cost data are in US$, and use of local currency requires separate currency conversion before inputing values in relevant fields."]
[]
["The tool consists of three worksheets:"]
["1.      Model inputs worksheet, where the user decides which vaccines to compare and adjusts data input relevant to country context."]
["2.      Results worksheet, where the user can consult costing projections."]
["3.      Charts worksheet, where these same results are displayed as charts."]
[]
["Disclaimer: The Pneumococcal conjugate vaccine choice: Cost comparison model is a cost calculator that aims to inform vaccine introduction decision-making and product selection. It is important to note that cost is only one consideration, and users involved in decision-making around new vaccine introduction or product selection should always consider other dimensions as well. This model is meant to provide insights into the potential costs of alternative product choices and should not replace detailed budget planning once a product has been selected."]
[]
["Model inputs worksheet "]
["On this worksheet, all boxes with a yellow background require user inputs. When available, default data are already entered, with the source of information indicated. Note that default data are only relevant for currently Gavi-eligible countries. Countries not eligible for Gavi support should confirm all data inputs individually. The three steps outlined below must be completed in order to obtain results. "]
[]
["Step 1: Immunization program"]
["Enter information related to the start year you want to explore, keeping in mind that this will be the first year of a 10-year program period. Enter the required information on your target population and annual population growth rate."]
[]
["Enter information related to expected vaccine coverage for dose 1, 2, and 3. You can use coverage estimates from your immunization program monitoring for antigens that are provided at the same time that PCV vaccine is administered. You can also choose to use coverage estimate targets or expected coverage estimates. Note that this will affect the number of doses required to sustain PCV vaccination activities."]
[]
["Step 2: Co-financing and financial support"]
["Indicate here if your country is currently in the Gavi initial self-financing phase or another transition phase. If your country is not eligible for any Gavi support, then enter 100% to indicate that your country supports the entire cost of vaccine procurement."]
[]
["If your country is in the Gavi initial self-financing phase, calculations of co-financing will be automatic, displaying co-financing per dose as per Gavi guidelines (i.e., $0.20 per dose for two-dose vaccines and $0.13 per dose for three-dose vaccines)."]
[]
["If your country is currently in another Gavi transition phase (preparatory transition or accelerated transition), enter your country’s co-financing share for each of the 10 years listed. If you are not aware of your country co-financing share, you should contact your Senior Country Manager."]
[]
["Finally, enter the amount of financial support your country may be eligible to receive for either a Gavi Vaccine Introduction Grant (VIG) or Gavi Switch Grant (SG). A box detailing how to calculate the VIG or SG is available on the right side of the worksheet. You may also consult the Gavi support guidelines for more information.  "]
["Gavi support guidelines"]
[]
["Step 3: PCV vaccine options"]
["The tool allows you to compare up to six different vaccine options at once. Use the drop-down menu to select each product you would like to compare. Each selection will automatically populate all of the product-related default data inputs in the rows below. All vaccine characteristics are from the Gavi detailed product profiles, including price per dose, number of doses in the schedule, and wastage rate."]
["Gavi detailed product profiles"]
[]
["Annual co-financing amount per dose cannot be changed as these are the results of calculations based on the vaccine price and co-financing share provided under Step 2."]
[]
["Next, adjust the following inputs based on local information:"]
["· Wastage rate: Though the tool extracts standard information for each product, you may want to alter this field with specific information from your country’s immunization program."]
["· International handling: This is a common UNICEF fee to cover procurement services. It is expressed as a percentage of the vaccine price. Standard rates are available on the UNICEF website."]
["UNICEF website - handling fees"]
["· International transportation: This corresponds to the cost for international shipping of vaccines and is expressed as a percentage of the vaccine price. Your local UNICEF office may be able to provide background information to help define this input value, using data from earlier shipments and invoices."]
["· Safety box price: Enter the price of the safety box as used in PCV immunization activities. Standard prices are available on the UNICEF website."]
["UNICEF website - pricing data"]
["· Safety box/bag volume: The number of doses that a box/bag can contain. This is required in order to calculate how many boxes/bags are required for PCV vaccination activities."]
[]
["The remaining inputs required on this worksheet are related to vaccine program costs. "]
[]
["For each vaccine being compared, enter the amount budgeted for the one-time introduction or switch costs. This should only include start-up costs, such as expenditures related to microplanning, training, or communication. Typically, this includes expenditures only occurring in the first year to start up the PCV program or switch vaccine products. "]
[]
["All other recurrent costs should be reflected in the incremental cost of delivery per dose for each vaccine being compared. Note that this might vary from one product to another based on product presentation, storage requirements, and ease of administration. You can find data on incremental cost per dose from a range of studies and countries through the Immunization Cost of Delivery Catalogue (IDCC)."]
["Immunization Cost of Delivery Catalogue (IDCC)"]
[]
["Here is a brief explanation of the type of costs to include in this calculation: "]
["· Program costs or incremental financial health system costs refer to all expenditures other than the direct cost of vaccines and commodities. Program costs should include any required expenditures related to staff time, per diem and travel allowances, cold chain equipment, vehicles, transport and fuel, program management, training and capacity building, social mobilization and advocacy, disease surveillance and activities related to adverse events following immunization (AEFI), and waste management."]
["· Financial costs refer to direct expenditures that will have to happen at the time of immunization activities. For example, this may include injection supplies, per diem or allowances for outreach activities, room rental for training, or similar related costs."]
["· Incremental costs refer to additional expenditures required for the delivery of PCV vaccine. Any system cost already incurred by the immunization system (shared costs) should be excluded. For example the cost of transporting PCV vaccine should not be included if this is part of the same transport used to deliver other vaccines. Only potential additional trips that may be needed should be included."]
[]
["After adjusting the data inputs for each vaccine option you want to compare, you will be ready to move to the results worksheet."]
[]
["Results worksheet"]
["The results worksheet presents cost information annually as well as a total over 10 years for the two different perspectives described above and per each vaccine option indicated in the model inputs worksheet."]
[]
["Results are displayed in three subsections:"]
[]
["1.      Immunization program"]
["This section provides results in terms of the number of doses delivered and the number of doses required for the PCV vaccination program. Number of doses required equals the number of doses delivered plus the number of doses wasted. This section also calculates the 10-year and annual requirements in terms of cold chain volume, accounting for each vaccine cold chain vaccine volume per dose multiplied by the total number of doses required. Please be aware that this total volume should be used only as an estimated indication as it will vary depending on the number of vaccine shipments per year and the country’s vaccine distribution system. Also, please note that some vaccines require negative cold chain at the central level and others include components that can be stored outside of the positive cold chain."]
[]
["2.      Country cost"]
["This section provides cost from only the country’s perspective. Vaccine cost, corresponding to vaccine and commodities procurement, is provided separately from total vaccination program cost, which includes vaccine costs and incremental health system costs."]
[]
["3.      Country and Gavi cost"]
["This section provides cost from both the country and Gavi perspectives (and is only relevant for Gavi-eligible countries). The subcategories are similar to what is found in the country cost subsection."]
[]
["Note: Conditional formatting is used in subsections 2 and 3 to highlight 10-year cost cells for the least costly vaccine option (dark green color) to the most costly vaccine option (yellow color)."]
[]
["Charts worksheet"]
["The charts worksheet provides a graphic representation of the same results seen on the previous worksheet. The same perspectives and subcategories are reported here. After completing your first analysis, if you make changes on the model inputs worksheet, the results and charts worksheets will automatically update with the new results."]
[]
["Calculation formulas used in the cost comparison tool"]
["Number of doses delivered = Birth cohort x coverage D1 + birth cohort x coverage D2 + birth cohort x coverage D3"]
["Total doses required = Number of doses delivered x wastage factor"]
["Total cold chain volume required = Cold chain volume per dose in cm3 x total doses required"]
["Wastage factor = (1 / (1 - wastage rate))"]
["Vaccine cost (country cost) = Total doses required x (co-financing amount per dose + co-financing amount per dose x international handling + co-financing amount per dose x international transportation) + (number of doses delivered / volume of safety box x price of safety box)"]
["Vaccination program cost (country cost) = Vaccine cost + number of doses delivered x incremental cost of delivery per dose + introduction or switching costs - VIG or SG (only in Year 1)"]
["Vaccine cost (country + Gavi cost) = Total doses required x (vaccine price per dose + vaccine price per dose x international handling + vaccine price per dose x international transportation) + (number of doses delivered / volume of safety box x price of safety box)"]
["Vaccination program cost (country + Gavi cost) = Vaccine cost + number of doses delivered x incremental cost of delivery per dose + introduction or switching costs (only in Year 1)"]

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[null,"Human papillomavirus (HPV) vaccine cost calculator"]
[]
[null,"User guide"]
[null,"For questions or support, contact PATH's Health Economics & Outcomes Research team: HEOR@path.org"]
[null,null,"Version 1.0  (January 2022)"]
[null,"The human papillomavirus (HPV) vaccine cost calculator is a simple tool for assessing and comparing costs of HPV vaccination programs with each HPV product available in the global market. It aims to help country-level policy-makers compare products and estimate vaccination program costs for different HPV vaccines, exploring up to six different vaccine options at a time. The tool can be used by any country interested in comparing different HPV vaccine costs, whether or not the country is eligible for co-funding from Gavi, the Vaccine Alliance. "]
[]
[null,"The tool calculates costs annually and for a total period of 10 years. Estimates of vaccine cost (i.e., vaccine and supplies procurement and international shipping) and vaccination program costs (i.e., vaccine cost and cost of delivery) are provided separately for two perspectives: (1) the country perspective and (2) the combined country and Gavi perspective (only relevant for Gavi-eligible countries). The country perspective accounts only for what is paid from the country budget, while the country and Gavi perspective also accounts for Gavi co-financing of vaccines and support grants. All cost data are in US$, and use of local currency requires separate currency conversion before inputing values in relevant fields."]
[]
[null,"Disclaimer: The human papillomavirus vaccine cost calculator is a tool that aims to inform vaccine introduction decision-making and product selection. It is important to note that cost is only one consideration, and users involved in decision-making around new vaccine introduction or product selection should always consider other dimensions as well. This tool is meant to provide insights into the potential costs of alternative product choices and should not replace cost-effectiveness modeling (value assessment) or detailed budget planning once a product has been selected."]
[null,"Model Overview"]
[]
[null,"The tool consists of three worksheets:"]
[null,"1.      Model inputs worksheet, where the user decides which vaccines to compare and adjusts data inputs relevant to country context and HPV program."]
[null,"2.      Results worksheet, where the user can consult costing projections. There are three separate results worksheets for each program population (girls 9-14 years old, boys, and girls 15+ and women)."]
[null,"3.      Charts worksheet, where these same results are displayed as charts."]
[]
[null,"Model inputs worksheet "]
[null,"On this worksheet, the user is asked to set up the tool to reflect the local HPV program and vaccine products of interest. Upon opening, the tool includes example inputs. However, all example inputs should be updated to reflect the local population, program, and inputs. The legend below explains the types of cells in the model inputs worksheet. The Steps for Using Tool described below must be completed in order to obtain results."]
[null,"Legend"]
[null,null,"Blue boxes indicate a dropdown menu from which the user can select a pre-specified choice. Click on the blue box and a dropdown arrow will appear. Clicking on the arrow will allow the user to select from a menu of options."]
[null,null,"Yellow boxes require user inputs. Example data are included in the model, but this information should be revised to reflect the local HPV program and inputs."]
[null,null,"White cells include information that is fixed and cannot be changed by the user."]
[]
[null,"Steps for Using Tool"]
[null,"Please choose \"Enable macros\" or \"Enable content\" upon opening this workbook."]
[null,"Step 1: Define the target population(s)"]
[null,"Step 1 allows the user to define the populations they would like to include in the analysis. The recommended target population for the HPV vaccine, girls 9-14 years old, is always included in the analysis. For each additional target population listed in Step 1 (girls 9-14 years old, boys, and girls 15+ years old and women), select whether to include that population in the vaccine program by selecting \"Yes\" or \"No\" from the adjacent dropdown menus. The tool will only ask for information on and calculate results for target populations that are selected for inclusion."]
[]
[null,"Step 2: Characterize the immunization program\n\nFor each selected target population, complete the following information:"]
[null,"Start year: Enter information related to the start year you want to explore, keeping in mind that this will be the first year of a 10-year program period. Enter the required information on your target population and annual population growth rate."]
[null,"Cohort type, age and target population size: Enter information on the age and size of each target population. For the girls 9-14 years old population only, enter age and target population size by type of cohort: single-aged cohort (e.g., routine), and multi-aged cohort (e.g., one-time campaign). If no multi-aged cohort is anticipated, enter target population size as 0 for each year."]
[null,"Delivery options: Enter the proportion of individuals reached via each delivery location (school, facility, or outreach). These entries must total 100%."]
[null,"Expected coverage by dose: Enter information related to expected vaccine coverage for dose 1, 2, and 3, as appropriate based on the immunization schedule of the target population. Because coverage by delivery location may vary, please enter coverage estimates for each delivery location. You can choose to use planned coverage target estimates, expected coverage estimates or actual coverage from past cohorts. Note that coverage estimates will affect the number of doses required to sustain HPV vaccination activities. If a particular dose (e.g., dose 3) is not part of your immunization schedule, enter 0 for the expected coverage across all delivery locations."]
[]
[null,"Step 3: Co-financing and financial support"]
[null,"Please note this tool only accounts for Gavi support for vaccination among girls 9-14 years old based on current Gavi vaccination funding guidelines."]
[null,"Gavi eligibility: First, indicate whether your country is Gavi-eligible by selecting \"Yes\" or \"No\" from the drop down menu. If yes, there will be an opportunity to add co-financing and financial support information for the target population of girls 9-14 years old. If no, 100% of program and vaccine costs will be assigned to the country. "]
[]
[null,"Co-financing for Gavi-eligible countries:"]
["Co-financing for Gavi-eligible countries:","1. If your country is Gavi eligible, indicate the country's Gavi transition phase by selecting the appropriate option in the drop-down menu."]
[null,{"$f":"\"2. If you select 'Initial self-financing', country co-financing will be assumed to be $\"&TEXT(cofin,\"0#.#0\")&\" per dose each year.\"","v":"2. If you select 'Initial self-financing', country co-financing will be assumed to be $0.20 per dose each year."}]
[null,"3. If your country is currently in another Gavi transition phase (preparatory transition or accelerated transition), select \"Other transition phase\" and enter your country’s co-financing share for each of the 10 years listed. If you are not aware of your country co-financing share, you should contact your Gavi Senior Country Manager."]
[null,"4. Enter the amount of financial support your country may be eligible to receive for either a Gavi Vaccine Introduction Grant (VIG) or Campaign Operational Support Grant (Ops). A box detailing how to calculate the VIG or Ops grant is available on the right side of the worksheet. You may also consult the Gavi support and vaccine funding guidelines for more information. Finally, enter the proportion of vaccine product cost covered by Gavi for multi-aged cohort doses (if applicable)."]
[null,"Gavi support guidelines (August 2021)"]
[null,"Gavi vaccine funding guidelines (August 2021)"]
[null,"Step 4: HPV vaccine options"]
[null,"The tool allows you to compare up to six different vaccine options at once including a placeholder for vaccines not yet available. Use the drop-down menu under each Option 1-6 (in cells C117:AK117) to select each product you would like to compare. This section incorporates product-specific characteristics, including price per dose, number of doses in the schedule, and wastage rate. In this section, many input values may be similar across product choices but inputs need to be entered for each vaccine option. See the Gavi detailed product profiles for more information on each vaccine option. "]
[null,"Gavi detailed product profiles"]
[null,"· Vaccine price and co-financing sections:"]
[null,"For Gavi countries, the vaccine price per dose to countries for programs targeting girls is automatically populated based on known or indicative tenders (current as of December 2021). Gavi does not provide subsidies for doses delivered to boys or girls 15+ years old and women; for these populations, enter the vaccine price you can access for each vaccine product option. "]
[null,"For non-Gavi countries, indicate the vaccine price you can access for each vaccine product option and target population included in the vaccine program. Information on vaccine price paid by other countries is available from the WHO/MI4A database ."]
[null,"WHO/MI4A Vaccine Purchase Database"]
[null,"For additional information on HPV vaccines, read the initial WHO Position paper (2017) and updated conclusions and recommendations from the Strategic Advisory Group of Experts (SAGE) on Immunization report (2019)."]
[null,"Position paper on HPV vaccines (May 2017)"]
[null,"SAGE Report (2019)"]
[]
[null,"Annual co-financing amount per dose cannot be changed as these are the results of calculations based on the vaccine price and co-financing share provided under Step 3."]
[null,"Next, adjust the following inputs based on local information for each target population included in the program:"]
[null,"· Number of doses in schedule: Indicate the number of doses to be given to each population in the program by selecting from the relevant drop down menus."]
[null,"· Wastage rate: An example wastage rate (e.g. 5%) is included as a default estimate for each vaccine product, however, this estimates should be revised to reflect the local program. If available, the Gavi-indicated wastage rate is auto-populated in the notes sidebar to support customization of this input parameter for each vaccine. However, if local wastage rates are available from your country’s immunization program, please revise to reflect local estimates."]
[null,"· International handling: This is a common UNICEF fee to cover procurement services. It is expressed as a percentage of the vaccine price. Standard rates are available on the UNICEF website and included as defaults in the tool, but this input may be revised as necessary to better reflect the local program."]
[null,"UNICEF website - handling fees"]
[null,"· International transportation: This corresponds to the cost for international shipping of vaccines and is expressed as a percentage of the vaccine price. An example % is included as a default parameter. Your local UNICEF office may be able to provide background information to help define this input value, using data from earlier shipments and invoices."]
[null,"· Safety box price: Enter the price of the safety box as used in HPV immunization activities. Standard prices are available on the UNICEF website."]
[null,"UNICEF website - pricing data"]
[null,"· Safety box/bag volume: The number of doses that a box/bag can contain. This is required in order to calculate how many boxes/bags are required for HPV vaccination activities. An example price per box and volume are included based on standard estimates from UNICEF but may need to be updated to better reflect the local program."]
[null,"· Syringe price: Enter the price of syringes as used in HPV immunization activities. Standard prices are available on the UNICEF website. The 2020 UNICEF mean price is included as a default but may need to be updated to reflect local procurement prices. "]
[null,"UNICEF website - pricing data"]
[]
[null,"The remaining inputs required on this worksheet are related to vaccine program costs. "]
[]
[null,"· Vaccination program costs"]
[null,"Vaccination program costs include vaccine introduction costs and incremental health system costs or incremental cost of delivery per dose:"]
[null,"Introduction costs include one-time costs of introducing the program in the first year (or switching products after the first year). This should only include start-up costs such as expenditures related to microplanning, initial training, or communication. Typically, this includes expenditures only occurring in the first year to start up the HPV program (may be applicable to single-aged cohort and multi-aged cohort or just the single-aged cohort, depending on program) or switch vaccine products (applicable to single-aged cohort only). For each vaccine being compared, enter the amount budgeted for the one-time introduction costs. "]
[null,"The incremental cost of delivery per dose refers to all additional expenditures required to deliver vaccines, other than the one-time introduction costs and the direct cost of vaccines procurement and commodities. These include additional required expenditures related to staff, per diem, travel allowances, cold chain equipment, vehicles, transport and fuel, program management, ongoing training and capacity building, ongoing social mobilization and advocacy, disease surveillance and activities related to adverse events following immunization (AEFI), and waste management. Any system cost already incurred by the immunization system (shared costs) should be excluded. For example the cost of transporting HPV vaccine should not be included if this is part of the same transport used to deliver other vaccines. Only potential additional trips that may be needed should be included. Note that the incremental delivery costs might vary from one product to another based on product presentation, storage requirements, and ease of administration. Importantly, delivery costs differ based on the program approach (school-based, facility-based, outreach). Please enter costs specific to each approach used by the program or enter $0 for any approach not used. You can find data on incremental cost per dose from a range of studies and countries through the Immunization Delivery Cost Catalogue (IDCC)."]
[null,"Immunization Delivery Cost Catalogue (IDCC)"]
[]
[null,"After adjusting the data inputs for each vaccine option you want to compare, you will be ready to move to the results worksheet."]
[]
[null,"Results worksheet"]
[null,"There are three separate results worksheets for each program population (girls 9-14 years old, boys, and girls 15+ and women). Each results worksheet presents cost information annually as well as a total over 10 years for the two different perspectives described above and per each vaccine option indicated in the model inputs worksheet."]
[]
[null,"For each vaccine option, results are displayed in three subsections:"]
[null,"1.      Immunization program"]
[null,"This section provides results in terms of the number of doses delivered and the number of doses required for the HPV vaccination program for that target population. Number of doses required equals the number of doses delivered plus the number of doses wasted."]
[]
[null,"2.      Country costs"]
[null,"This section provides costs from only the country’s perspective. Vaccine cost, corresponding to vaccine and commodities procurement, is provided separately from total vaccination program cost, which includes vaccine costs and incremental health system costs."]
[]
[null,"3.      Country and Gavi costs"]
[null,"This section provides costs from both the country and Gavi perspectives (and is only relevant for Gavi-eligible countries). The subcategories are similar to what is found in the country cost subsection."]
[]
[null,"Note: Conditional formatting is used in subsections 2 (country costs) and 3 (country + Gavi costs) to highlight 10-year cost cells for the least costly vaccine option (dark green color) to the most costly vaccine option (yellow color)."]
[]
[null,"Charts worksheet"]
[null,"The charts worksheets provide a graphical representation of the same results seen on the results worksheets. The same perspectives and subcategories are reported here. After completing your first analysis, if you make changes on the model inputs worksheet, the results and charts worksheets will automatically update with the new results."]
[]
[null,"Calculation formulas used in the cost tool*†"]
[null,"Number of doses delivered = Target cohort(s) x delivery location-weighted coverage dose 1 + target cohort(s) x delivery location-weighted coverage dose 2 + target cohort(s) x delivery location-weighted coverage dose 3\n(Note: delivery location = school, facility or outreach)"]
[null,"Total doses required = Number of doses delivered x wastage factor"]
[null,"Wastage factor = (1 / (1 - wastage rate))"]
[null,"Vaccine cost (country cost) = Total doses required x (co-financing amount per dose + co-financing amount per dose x international handling + co-financing amount per dose x international transportation) + (number of doses delivered / volume of safety box x price of safety box) + (number of doses delivered x price of syringe)"]
[null,"Vaccination program cost (country cost) = Vaccine cost + number of doses delivered x incremental cost of delivery per dose + introduction or switching costs - any subsidies (e.g., VIG/Ops grants, multi-age cohort cost per dose)"]
[null,"Vaccine cost (country + Gavi cost) = Total doses required x (vaccine price per dose + vaccine price per dose x international handling + vaccine price per dose x international transportation) + (number of doses delivered / volume of safety box x price of safety box) + (number of doses delivered x price of syringe)"]
[null,"Vaccination program cost (country + Gavi cost) = Vaccine cost + number of doses delivered x incremental cost of delivery per dose + introduction or switching costs"]
[]
[null,"* x = multiply"]
[null,"†Note that for the program for girls 9-14 years old, estimates reflect the cohorts indicated (e.g., single-aged cohort only if no multi-aged cohort is included or combined single-aged cohort and a one-time multi-aged cohort)."]

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["Human papillomavirus (HPV) vaccine cost calculator",null,null,null,null,null,null,null,null,"Version 1.0 / December 2021"]
["A simplified model to assess and compare costs of HPV vaccination programs with each HPV vaccine product available in the global market",null,null,null,null,null,null,null,null,"For questions or support, contact PATH's Health Economics and Outcomes Research team: \nHEOR@path.org"]
[]
[]
[null,null,"The HPV vaccine cost calculator is a tool that helps countries compare products and estimated vaccination program costs for different HPV vaccines, exploring up to six different vaccine options at a time. Costs are calculated annually and for a total period of 10 years. All boxes with a yellow background require user inputs and blue boxes require the user to select from a drop-down menu (click on the cell to activate the dropdown). When available, default data are already entered, with the source of information indicated; however, data should be updated to reflect the local program. Note that default data are for currently Gavi-eligible countries. Countries not eligible for Gavi support should confirm all data inputs individually. The tool generates projected costs based on the best currently available information for each vaccine. All cost data are in US$, and use of local currency requires separate currency conversion to US$ before inputing values in relevant fields."]
[]
[]
[]
[]
[null,null,"â START HERE â",null,null,"Please be sure to complete all inputs on this tab for the following four steps before going to the Results tab:"]
[null,null,"STEP 1: DEFINE THE TARGET POPULATION(S)",null,null,"- Step 1: Define the target populations(s) "]
[null,null,"Target population","Included in vaccine program?",null,"- Step 2: Characterize the immunization program"]
[null,null,null,null,null,"- Step 3: Co-financing and financial support"]
[null,null,"Girls <15 years old\n(Included for all analyses)","Yes",null,"- Step 4: HPV vaccine options"]
[]
[null,null,"Boys","Yes",null,"Disclaimer: The HPV vaccine cost calculator is a tool that aims to inform vaccine introduction decision-making and product selection. It is important to note that cost is only one consideration, and users involved in decision-making around vaccine introduction or product selection should always consider other dimensions as well. This tool is meant to provide insights into the potential costs of alternative product choices and should not replace cost-effectiveness modeling (value assessment) or detailed budget planning once a product has been selected. "]
[]
[null,null,"Girls 15+ years and women","Yes"]
[]
[null,null,"STEP 2. CHARACTERIZE THE IMMUNIZATION PROGRAM"]
[]
[null,"GIRLS 9-14 YEARS OLD","HPV VACCINATION AMONG GIRLS 9-14 YEARS OLD"]
[null,null,"Start year (year 1)",null,2022,null,null,null,null,null,"Single-aged cohort (SAC) is the routine immunization cohort to be vaccinated annually.\n\nMulti-aged cohort (MAC) is a group of girls in addition to the routine cohort who will be immunized on a one-time basis (most frequently the first year of the immunization program). Select the MAC age range by selecting the youngest MAC age (\"Age from\") in cell H26 to the oldest MAC age included (\"To\") in cell J26.\n\nEnter the anticipated target population size (children per year) for each program year for the SAC and MAC populations. If no MAC is anticipated, enter target population size as 0 for each year."]
[null,null,"Cohort type",null,"Single-aged cohort (SAC)",null,null,"Multi-aged cohort (MAC)"]
[null,null,null,null,"For single-aged cohort (routine)",null,null,"Age from","For multi-aged cohort \n(one-time campaign)","To"]
[null,null,null,null,"Age","Target population size",null,10,"Target population size",14]
[null,null,{"$f":"E23","v":2022},null,9,100000,null,400000]
[null,null,{"$f":"C27+1","v":2023},null,9,100000,null,0]
[null,null,{"$f":"C28+1","v":2024},null,9,100000,null,0]
[null,null,2025,null,9,100000,null,0]
[null,null,2026,null,9,100000,null,0]
[null,null,2027,null,9,100000,null,0]
[null,null,2028,null,9,100000,null,0]
[null,null,2029,null,9,100000,null,0]
[null,null,2030,null,9,100000,null,0]
[null,null,2031,null,9,100000,null,0]
[null,null,"Delivery options ",null,"School","Facility","Outreach","School","Facility","Outreach"]
[null,null,null,null,0.25,0.25,0.5,0.9,0.1,0,"For both the SAC and MAC, enter the proportion of girls reached through each location (must total 100%)"]
[null,null,"Expected coverage dose 1",null,0.75,0.8,0.8,0.75,0.8,0.8,"Annual coverage for dose 1 by delivery location. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[null,null,"Expected coverage dose 2",null,0.7,0.75,0.75,0.7,0.75,0.75,"Annual coverage by delivery location. If fewer than 2 doses are given, enter 0%. Note: This is total dose 2 coverage and not  proportion of the dose 1 population. Dose 2 coverage is typically lower than dose 1 due to attrition. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[null,null,"Expected coverage dose 3",null,0,0,0,0,0,0,"Annual coverage by delivery location. If fewer than 3 doses are given, enter 0%. Note: This is total dose 3 coverage and not  proportion of the dose 2 population. Dose 3 coverage is typically lower than dose 2 due to attrition. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[]
[null,"BOYS","HPV VACCINATION AMONG ADDITIONAL POPULATIONS: BOYS"]
[null,null,"Start year (year 1)",null,2022]
[null,null,null,null,"Age","Target population size",null,"Select the target age for immunization in the blue drop down cells under \"Age\". In the yellow cells, enter the anticipated target population size for each program year. \n\nIf no vaccination among this population is anticipated in a given year, select \"NA\" for age and enter 0 for target population size for that year."]
[null,null,{"$f":"E44","v":2022},null,9,100000]
[null,null,{"$f":"C46+1","v":2023},null,9,100000]
[null,null,{"$f":"C47+1","v":2024},null,9,100000]
[null,null,2025,null,9,100000]
[null,null,2026,null,9,100000]
[null,null,2027,null,9,100000]
[null,null,2028,null,9,100000]
[null,null,2029,null,9,100000]
[null,null,2030,null,9,100000]
[null,null,2031,null,9,100000]
[null,null,"Delivery options ",null,"School","Facility","Outreach"]
[null,null,null,null,0.7,0.15,0.15,"Enter the proportion reached through each location (must total 100%)"]
[null,null,"Expected coverage dose 1",null,0.75,0.8,0.8,"Annual coverage for dose 1 by delivery location. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[null,null,"Expected coverage dose 2",null,0.7,0.75,0.75,"Annual coverage by delivery location. If fewer than 2 doses are given, enter 0%. Note: This is total dose 2 coverage and not  proportion of the dose 1 population. Dose 2 coverage is typically lower than dose 1 due to attrition. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[null,null,"Expected coverage dose 3",null,0,0,0,"Annual coverage by delivery location. If fewer than 3 doses are given, enter 0%. \nNote: This is total dose 3 coverage and not  proportion of the dose 2 population. Dose 3 coverage is typically lower than dose 2 due to attrition. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[]
[null,"GIRLS 15+ AND WOMEN","HPV VACCINATION AMONG ADDITIONAL POPULATIONS: GIRLS 15+ AND WOMEN"]
[null,null,"Start year (year 1)",null,2022]
[null,null,null,null,"Target population size",null,null," In the yellow cells, enter the anticipated target population size for each program year. \n\nIf no vaccination among this population is anticipated in a given year, enter 0 for that year."]
[null,null,{"$f":"E63","v":2022},null,1000]
[null,null,{"$f":"C65+1","v":2023},null,1000]
[null,null,{"$f":"C66+1","v":2024},null,1000]
[null,null,2025,null,1000]
[null,null,2026,null,2800]
[null,null,2027,null,3000]
[null,null,2028,null,3200]
[null,null,2029,null,3400]
[null,null,2030,null,3600]
[null,null,2031,null,3800]
[null,null,"Delivery options ",null,"School","Facility","Outreach"]
[null,null,null,null,0.7,0.15,0.15,"Enter the proportion reached through each location (must total 100%)"]
[null,null,"Expected coverage dose 1",null,0.75,0.8,0.8,"Annual coverage for dose 1 by delivery location. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[null,null,"Expected coverage dose 2",null,0.7,0.75,0.75,"Annual coverage by delivery location. If fewer than 2 doses are given, enter 0%. Note: This is total dose 2 coverage and not  proportion of the dose 1 population. Dose 2 coverage is typically lower than dose 1 due to attrition. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[null,null,"Expected coverage dose 3",null,0.65,0.7,0.7,"Annual coverage by delivery location. If fewer than 3 doses are given, enter 0%. \nNote: This is total dose 3 coverage and not  proportion of the dose 2 population. Dose 3 coverage is typically lower than dose 2 due to attrition. Where possible, historical program data should be used to reflect the most likely coverage estimates."]
[]
[]
[null,null,"STEP 3: GAVI ELIGIBILITY AND CO-FINANCING",null,null,null,null,null,null,"Gavi Support Guidelines"]
[null,null,"Please note this tool only accounts for Gavi support for vaccination among girls 9-14 years old based on current Gavi vaccination funding guidelines. Within this age range, countries may request support for a single age cohort to be vaccinated annually in routine immunization, either with or without additional multi-age cohorts. See side box and link below for additional support guidelines and information.",null,null,null,null,null,null,"Gavi support for HPV vaccination varies based on the country's Gavi transition phase and implementation strategy:"]
[]
[null,null,"https://www.gavi.org/sites/default/files/support/Vaccine_FundingGuidelines.pdf",null,null,null,null,null,null,"1.  Routine immunization among a single-aged cohort only:"]
[null,null,"Is this country Gavi eligible?  ","Yes","If yes, there will be an opportunity to add co-financing and financial support information for the girls program. \nIf no, 100% of program and vaccine costs will be assigned to country. ",null,null,null,null,"VIG provided at $2.40 per target girl in routine cohort or a lump sum of $100,000, whichever is higher, in year of introduction."]
[null,null,null,null,null,null,null,null,null,"2. Routine annual immunization among a single-aged cohort with additional one-time vaccination of a multi-age cohort (\"MAC\"): "]
[null,null,"CO-FINANCING AND FINANCIAL SUPPORT FOR PROGRAM FOR GIRLS 9-14 YEARS OLD ONLY"]
[null,null,null,null,"Notes",null,null,null,null,"VIG provided at $2.40 per target girl in routine cohort or a lump sum of $100,000, whichever is higher, in year of introduction."]
[null,null,"Gavi transition phase","Other transition phase","Please select the appropriate option in drop-down menu to the left. \nIf you select 'Initial self-financing', country co-financing will be assumed to be $0.20 per dose each year.\nIf you select 'Other transition phase', fill in the country co-financing share for each year listed below. The details in this section apply only to the girls program.",null,null,null,null,"Operational Support Grant is provided to countries that choose to include one-time vaccination of additional girls 9-14 years old that are not part of the routine cohort (i.e., a MAC). This grant is provided only in the year of the MAC and the per-dose amount varies by the country's Gavi transition phase as follows:"]
[null,null,"Country co-financing share "]
[null,null,{"$f":"E23","v":2022},0.15,"% of vaccine price per dose or \"price fraction\"\n\nNot used if you selected \"Initial self-financing phase\" above.\n\nIf you don't know your country co-financing share, contact your SCM.\n\nIf your country is scheduled to move from initial self-financing to preparatory transition during the 10-year period, contact HEOR@path.org to discuss how to set up the model."]
[null,null,{"$f":"C92+1","v":2023},0.25,null,null,null,null,null,"a. Initial-self financing pase: $0.65 per dose"]
[null,null,2024,0.3,null,null,null,null,null,"b. Preparatory transition phase: $0.55 per dose"]
[null,null,2025,0.35,null,null,null,null,null,"c. Accelerated transition phase: $0.45 per dose"]
[null,null,2026,0.4,null,null,null,null,null,"Countries including a one-time MAC receive vaccine supply for the additional girls at no cost in the year of the MAC. Standard country co-financing for the routine cohort vaccine supply is required."]
[null,null,2027,0.5]
[null,null,2028,0.6]
[null,null,2029,0.7]
[null,null,2030,0.8,null,null,null,null,null,"Please note that Gavi funding is provided only for vaccination of girls 9-14 years. Countries interested in vaccinating other populations (girls 15+ and women; boys) may still receive the VIG and/or Operational Support Grant for support in vaccinating girls 9-14 years, but will be required to cover the full operational and vaccine costs of reaching any additional populations included in the country's HPV immunization strategy."]
[null,null,2031,1]
[null,null,"Gavi Vaccine Introduction Grant (VIG) per dose for SAC in the first year",2.4,"VIGs are one-time subsidies provided by Gavi to offset a share of the costs related to introducing a new vaccine; standard country co-financing for vaccine supply is required. See side box for additional information."]
[null,null,"Gavi Campaign Operational Support (Ops) Grant per dose for MAC in the MAC year only",0.55000000000000004,"The Ops Grant is provided to countries that choose to include one-time vaccination of additional girls 9-14 years old that are not part of the routine cohort (i.e., the MAC). This grant is provided only in the year of the multi-age cohort for operational costs. See side box for additional information and current support."]
[]
[]
[null,null,"Gavi subsidy for multi-aged cohort doses \n(% cost coverage per dose)",1,"This covers the vaccine product cost for MAC doses during the MAC year only. Note that this input should only be changed from 100% if Gavi will not be subsidizing the country's MAC doses in full."]
[]
[]
[]
[]
[null,null,"STEP 4: HPV VACCINE OPTIONS                                                                               "]
[null,null,"For detailed HPV vaccine profiles visit:"]
[null,null,"Gavi website"]
[null,null,"VACCINE COST",null,null,null,null,null,null,null,null,null,null,null,"VACCINE COST",null,null,null,null,null,null,null,null,null,null,null,"VACCINE COST"]
[]
[null,null,"OPTION 1",null,null,null,null,null,"OPTION 2",null,null,null,null,null,"OPTION 3",null,null,null,null,null,"OPTION 4",null,null,null,null,null,"OPTION 5",null,null,null,null,null,"OPTION 6"]
[null,null,"Select vaccine and presentation >>>","Cecolin, bivalent",null,null,null,null,"Select vaccine and presentation >>>","Cecolin, bivalent",null,null,null,null,"Select vaccine and presentation >>>","Cervarix, bivalent, 10",null,null,null,null,"Select vaccine and presentation >>>","Gardasil-4, quadrivalent",null,null,null,null,"Select vaccine and presentation >>>","Gardasil-9, nonavalent",null,null,null,null,"Select vaccine and presentation >>>","Future vaccine to be defined by user (e.g. Zerun, bivalent)"]
[]
[null,null,null,"Girls 9-14 program","Boys program","Girls 15+ and women program ",null,null,null,"Girls 9-14 program","Boys program ","Girls 15+ and women program ",null,null,null,"Girls 9-14 program","Boys program ","Girls 15+ and women program ",null,null,null,"Girls 9-14 program","Boys program ","Girls 15+ and women program ",null,null,null,"Girls 9-14 program","Boys program ","Girls 15+ and women program ",null,null,null,"Girls 9-14 program","Boys program ","Girls 15+ and women program "]
[null,null,"Total vaccine price per dose",4.5,10,10,"Default data for the girls program is based on known or indicative Gavi tenders for this product. \nCecolin, bivalent: $3.00 per dose\nCervarix, bivalent: $5.18 per dose\nCervarix, bivalent, 10: unknown \nGardasil-4, quadrivalent: $4.50 per doce\nGardasil-9, nonavalent: $6.90 per doce\nFuture vaccine: unknown \n\nThese prices should be updated to reflect expected local procurement prices for non-Gavi countries. For future products or products where Gavi tenders are not known, example estimates are provided as defaults (to be updated for analysis).\nDefault pricing for boys and women are stylistic examples only and need to be updated by the user. If no programs are in place for boys or girls 15+ and women, then no data can be entered in those columns.",null,"Total vaccine price per dose",5.18,10,10,"Default data for the girls program is based on known or indicative Gavi tenders for this product. \nCecolin, bivalent: $3.00 per dose\nCervarix, bivalent: $5.18 per dose\nCervarix, bivalent, 10: unknown \nGardasil-4, quadrivalent: $4.50 per doce\nGardasil-9, nonavalent: $6.90 per doce\nFuture vaccine: unknown \n\nThese prices should be updated to reflect expected local procurement prices for non-Gavi countries. For future products or products where Gavi tenders are not known, example estimates are provided as defaults (to be updated for analysis).\nDefault pricing for boys and women are stylistic examples only and need to be updated by the user. If no programs are in place for boys or girls 15+ and women, then no data can be entered in those columns.",null,"Total vaccine price per dose",3,10,10,"Default data for the girls program is based on known or indicative Gavi tenders for this product. \nCecolin, bivalent: $3.00 per dose\nCervarix, bivalent: $5.18 per dose\nCervarix, bivalent, 10: unknown \nGardasil-4, quadrivalent: $4.50 per doce\nGardasil-9, nonavalent: $6.90 per doce\nFuture vaccine: unknown \n\nThese prices should be updated to reflect expected local procurement prices for non-Gavi countries. For future products or products where Gavi tenders are not known, example estimates are provided as defaults (to be updated for analysis).\nDefault pricing for boys and women are stylistic examples only and need to be updated by the user. If no programs are in place for boys or girls 15+ and women, then no data can be entered in those columns.",null,"Total vaccine price per dose",5.18,10,10,"Default data for the girls program is based on known or indicative Gavi tenders for this product. \nCecolin, bivalent: $3.00 per dose\nCervarix, bivalent: $5.18 per dose\nCervarix, bivalent, 10: unknown \nGardasil-4, quadrivalent: $4.50 per doce\nGardasil-9, nonavalent: $6.90 per doce\nFuture vaccine: unknown \n\nThese prices should be updated to reflect expected local procurement prices for non-Gavi countries. For future products or products where Gavi tenders are not known, example estimates are provided as defaults (to be updated for analysis).\nDefault pricing for boys and women are stylistic examples only and need to be updated by the user. If no programs are in place for boys or girls 15+ and women, then no data can be entered in those columns.",null,"Total vaccine price per dose",6.9,10,10,"Default data for the girls program is based on known or indicative Gavi tenders for this product. \nCecolin, bivalent: $3.00 per dose\nCervarix, bivalent: $5.18 per dose\nCervarix, bivalent, 10: unknown \nGardasil-4, quadrivalent: $4.50 per doce\nGardasil-9, nonavalent: $6.90 per doce\nFuture vaccine: unknown \n\nThese prices should be updated to reflect expected local procurement prices for non-Gavi countries. For future products or products where Gavi tenders are not known, example estimates are provided as defaults (to be updated for analysis).\nDefault pricing for boys and women are stylistic examples only and need to be updated by the user. If no programs are in place for boys or girls 15+ and women, then no data can be entered in those columns.",null,"Total vaccine price per dose",3,3,3,"Default data for the girls program is based on known or indicative Gavi tenders for this product. \nCecolin, bivalent: $3.00 per dose\nCervarix, bivalent: $5.18 per dose\nCervarix, bivalent, 10: unknown \nGardasil-4, quadrivalent: $4.50 per doce\nGardasil-9, nonavalent: $6.90 per doce\nFuture vaccine: unknown \n\nThese prices should be updated to reflect expected local procurement prices for non-Gavi countries. For future products or products where Gavi tenders are not known, example estimates are provided as defaults (to be updated for analysis).\nDefault pricing for boys and women are stylistic examples only and need to be updated by the user. If no programs are in place for boys or girls 15+ and women, then no data can be entered in those columns."]
[null,null,"Country financing share per dose",null,null,null,null,null,"Co-financing amount per dose",null,null,null,null,null,"Co-financing amount per dose",null,null,null,null,null,"Co-financing amount per dose",null,null,null,null,null,"Co-financing amount per dose",null,null,null,null,null,"Co-financing amount per dose"]
[null,null,{"$f":"$E$23","v":2022},{"$f":"IF($D$86=\"No\",D$120,IF($D$90=\"Other transition phase\",$D92*D$120,IF(AND(D$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":0.67499999999999993},{"$f":"$E$120","v":10},{"$f":"$F$120","v":10},"-",null,{"$f":"$E$23","v":2022},{"$f":"IF($D$86=\"No\",J$120,IF($D$90=\"Other transition phase\",$D92*J$120,IF(AND(J$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":0.77699999999999991},{"$f":"$K$120","v":10},{"$f":"$L$120","v":10},"-",null,{"$f":"$E$23","v":2022},{"$f":"IF($D$86=\"No\",P$120,IF($D$90=\"Other transition phase\",$D92*P$120,IF(AND(P$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":0.44999999999999996},{"$f":"$Q$120","v":10},{"$f":"$R$120","v":10},"-",null,{"$f":"$E$23","v":2022},{"$f":"IF($D$86=\"No\",V$120,IF($D$90=\"Other transition phase\",$D92*V$120,IF(AND(V$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":0.77699999999999991},{"$f":"$W$120","v":10},{"$f":"$X$120","v":10},"-",null,{"$f":"$E$23","v":2022},{"$f":"IF($D$86=\"No\",AB$120,IF($D$90=\"Other transition phase\",$D92*AB$120,IF(AND(AB$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":1.0349999999999999},{"$f":"$AC$120","v":10},{"$f":"$AD$120","v":10},"-",null,{"$f":"$E$23","v":2022},{"$f":"IF($D$86=\"No\",AH$120,IF($D$90=\"Other transition phase\",$D92*AH$120,IF(AND(AH$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":0.44999999999999996},{"$f":"$AI$120","v":3},{"$f":"$AJ$120","v":3},"-"]
[null,null,{"$f":"C122+1","v":2023},{"$f":"IF($D$86=\"No\",D$120,IF($D$90=\"Other transition phase\",$D93*D$120,IF(AND(D$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":1.125},{"$f":"$E$120","v":10},{"$f":"$F$120","v":10},"-",null,{"$f":"I122+1","v":2023},{"$f":"IF($D$86=\"No\",J$120,IF($D$90=\"Other transition phase\",$D93*J$120,IF(AND(J$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":1.2949999999999999},{"$f":"$K$120","v":10},{"$f":"$L$120","v":10},"-",null,{"$f":"O122+1","v":2023},{"$f":"IF($D$86=\"No\",P$120,IF($D$90=\"Other transition phase\",$D93*P$120,IF(AND(P$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":0.75},{"$f":"$Q$120","v":10},{"$f":"$R$120","v":10},"-",null,{"$f":"U122+1","v":2023},{"$f":"IF($D$86=\"No\",V$120,IF($D$90=\"Other transition phase\",$D93*V$120,IF(AND(V$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":1.2949999999999999},{"$f":"$W$120","v":10},{"$f":"$X$120","v":10},"-",null,{"$f":"AA122+1","v":2023},{"$f":"IF($D$86=\"No\",AB$120,IF($D$90=\"Other transition phase\",$D93*AB$120,IF(AND(AB$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":1.7250000000000001},{"$f":"$AC$120","v":10},{"$f":"$AD$120","v":10},"-",null,{"$f":"AG122+1","v":2023},{"$f":"IF($D$86=\"No\",AH$120,IF($D$90=\"Other transition phase\",$D93*AH$120,IF(AND(AH$132=2,$D$90=\"Initial self-financing phase\"),0.2,0.2)))","v":0.75},{"$f":"$AI$120","v":3},{"$f":"$AJ$120","v":3},"-"]
[null,null,{"$f":"C123+1","v":2024},1.3499999999999999,10,10,"-",null,{"$f":"I123+1","v":2024},1.5539999999999998,10,10,"-",null,{"$f":"O123+1","v":2024},0.89999999999999991,10,10,"-",null,{"$f":"U123+1","v":2024},1.5539999999999998,10,10,"-",null,{"$f":"AA123+1","v":2024},2.0699999999999998,10,10,"-",null,{"$f":"AG123+1","v":2024},0.89999999999999991,3,3,"-"]
[null,null,2025,1.575,10,10,"-",null,2025,1.8129999999999997,10,10,"-",null,2025,1.0499999999999998,10,10,"-",null,2025,1.8129999999999997,10,10,"-",null,2025,2.415,10,10,"-",null,2025,1.0499999999999998,3,3,"-"]
[null,null,2026,1.8,10,10,"-",null,2026,2.0720000000000001,10,10,"-",null,2026,1.2000000000000002,10,10,"-",null,2026,2.0720000000000001,10,10,"-",null,2026,2.7600000000000002,10,10,"-",null,2026,1.2000000000000002,3,3,"-"]
[null,null,2027,2.25,10,10,"-",null,2027,2.59,10,10,"-",null,2027,1.5,10,10,"-",null,2027,2.59,10,10,"-",null,2027,3.45,10,10,"-",null,2027,1.5,3,3,"-"]
[null,null,2028,2.6999999999999997,10,10,"-",null,2028,3.1079999999999997,10,10,"-",null,2028,1.7999999999999998,10,10,"-",null,2028,3.1079999999999997,10,10,"-",null,2028,4.1399999999999997,10,10,"-",null,2028,1.7999999999999998,3,3,"-"]
[null,null,2029,3.15,10,10,"-",null,2029,3.6259999999999994,10,10,"-",null,2029,2.0999999999999996,10,10,"-",null,2029,3.6259999999999994,10,10,"-",null,2029,4.83,10,10,"-",null,2029,2.0999999999999996,3,3,"-"]
[null,null,2030,3.6,10,10,"-",null,2030,4.1440000000000001,10,10,"-",null,2030,2.4000000000000004,10,10,"-",null,2030,4.1440000000000001,10,10,"-",null,2030,5.5200000000000005,10,10,"-",null,2030,2.4000000000000004,3,3,"-"]
[null,null,2031,4.5,10,10,"-",null,2031,5.18,10,10,"-",null,2031,3,10,10,"-",null,2031,5.18,10,10,"-",null,2031,6.9,10,10,"-",null,2031,3,3,3,"-"]
[null,null,"Number of doses in schedule",2,2,3,"NOTE TO PROGRAMMER: THIS ROW IS NOT IN USE.",null,"Number of doses in schedule",2,2,3,"NOTE TO PROGRAMMER: THIS ROW IS NOT IN USE.",null,"Number of doses in schedule",2,2,3,"NOTE TO PROGRAMMER: THIS ROW IS NOT IN USE.",null,"Number of doses in schedule",2,2,3,"NOTE TO PROGRAMMER: THIS ROW IS NOT IN USE.",null,"Number of doses in schedule",2,2,3,"NOTE TO PROGRAMMER: THIS ROW IS NOT IN USE.",null,"Number of doses in schedule",2,2,3,"NOTE TO PROGRAMMER: THIS ROW IS NOT IN USE."]
[null,null,"Wastage rate",0.05,0.05,0.05,"The following wastage estimates are indicated per Gavi’s HPV Vaccine Profile (May 2021). \nCecolin, bivalent: 5%\nCervarix, bivalent: 10%\nCervarix, bivalent, 10: no estimate reported\nGardasil-4, quadrivalent: 5%\nGardasil-9, nonavalent: 5%\nFuture vaccine: no estimate reported\n\nUser can input this value or use local estimates. ",null,"Wastage rate",0.05,0.05,0.05,"The following wastage estimates are indicated per Gavi’s HPV Vaccine Profile (May 2021). \nCecolin, bivalent: 5%\nCervarix, bivalent: 10%\nCervarix, bivalent, 10: no estimate reported\nGardasil-4, quadrivalent: 5%\nGardasil-9, nonavalent: 5%\nFuture vaccine: no estimate reported\n\nUser can input this value or use local estimates. ",null,"Wastage rate",0.05,0.05,0.05,"The following wastage estimates are indicated per Gavi’s HPV Vaccine Profile (May 2021). \nCecolin, bivalent: 5%\nCervarix, bivalent: 10%\nCervarix, bivalent, 10: no estimate reported\nGardasil-4, quadrivalent: 5%\nGardasil-9, nonavalent: 5%\nFuture vaccine: no estimate reported\n\nUser can input this value or use local estimates. ",null,"Wastage rate",0.05,0.05,0.05,"The following wastage estimates are indicated per Gavi’s HPV Vaccine Profile (May 2021). \nCecolin, bivalent: 5%\nCervarix, bivalent: 10%\nCervarix, bivalent, 10: no estimate reported\nGardasil-4, quadrivalent: 5%\nGardasil-9, nonavalent: 5%\nFuture vaccine: no estimate reported\n\nUser can input this value or use local estimates. ",null,"Wastage rate",0.05,0.05,0.05,"The following wastage estimates are indicated per Gavi’s HPV Vaccine Profile (May 2021). \nCecolin, bivalent: 5%\nCervarix, bivalent: 10%\nCervarix, bivalent, 10: no estimate reported\nGardasil-4, quadrivalent: 5%\nGardasil-9, nonavalent: 5%\nFuture vaccine: no estimate reported\n\nUser can input this value or use local estimates. ",null,"Wastage rate",0.05,0.05,0.05,"The following wastage estimates are indicated per Gavi’s HPV Vaccine Profile (May 2021). \nCecolin, bivalent: 5%\nCervarix, bivalent: 10%\nCervarix, bivalent, 10: no estimate reported\nGardasil-4, quadrivalent: 5%\nGardasil-9, nonavalent: 5%\nFuture vaccine: no estimate reported\n\nUser can input this value or use local estimates. "]
[null,null,"Wastage factor",{"$f":"(1/(1-D133))","v":1.0526315789473684},{"$f":"(1/(1-E133))","v":1.0526315789473684},{"$f":"(1/(1-F133))","v":1.0526315789473684},"https://www.gavi.org/sites/default/files/support/Gavi_HPV_vaccine_profiles.pdf",null,"Wastage factor",{"$f":"(1/(1-J133))","v":1.0526315789473684},{"$f":"(1/(1-K133))","v":1.0526315789473684},{"$f":"(1/(1-L133))","v":1.0526315789473684},"https://www.gavi.org/sites/default/files/support/Gavi_HPV_vaccine_profiles.pdf",null,"Wastage factor",{"$f":"(1/(1-P133))","v":1.0526315789473684},{"$f":"(1/(1-Q133))","v":1.0526315789473684},{"$f":"(1/(1-R133))","v":1.0526315789473684},"https://www.gavi.org/sites/default/files/support/Gavi_HPV_vaccine_profiles.pdf",null,"Wastage factor",{"$f":"(1/(1-V133))","v":1.0526315789473684},{"$f":"(1/(1-W133))","v":1.0526315789473684},{"$f":"(1/(1-X133))","v":1.0526315789473684},"https://www.gavi.org/sites/default/files/support/Gavi_HPV_vaccine_profiles.pdf",null,"Wastage factor",{"$f":"(1/(1-AB133))","v":1.0526315789473684},{"$f":"(1/(1-AC133))","v":1.0526315789473684},{"$f":"(1/(1-AD133))","v":1.0526315789473684},"https://www.gavi.org/sites/default/files/support/Gavi_HPV_vaccine_profiles.pdf",null,"Wastage factor",{"$f":"(1/(1-AH133))","v":1.0526315789473684},{"$f":"(1/(1-AI133))","v":1.0526315789473684},{"$f":"(1/(1-AJ133))","v":1.0526315789473684},"https://www.gavi.org/sites/default/files/support/Gavi_HPV_vaccine_profiles.pdf"]
[null,null,"International handling",0.03,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs is 4%; Default for new vaccines is 3%",null,"International handling",0.03,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs is 4%; Default for new vaccines is 3%",null,"International handling",0.03,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs is 4%; Default for new vaccines is 3%",null,"International handling",0.03,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs is 4%; Default for new vaccines is 3%",null,"International handling",0.03,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs is 4%; Default for new vaccines is 3%",null,"International handling",0.03,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs is 4%; Default for new vaccines is 3%"]
[null,null,"International transportation",7.0000000000000007E-2,null,null,"as a % of vaccine price;\nDefault: example %",null,"International transportation",7.0000000000000007E-2,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs",null,"International transportation",7.0000000000000007E-2,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs",null,"International transportation",7.0000000000000007E-2,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs",null,"International transportation",7.0000000000000007E-2,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs",null,"International transportation",7.0000000000000007E-2,null,null,"as a % of vaccine price;\nDefault: UNICEF % for LDCs"]
[null,null,"Safety box price",0.56999999999999995,null,null,"Default: UNICEF mean price (2020)",null,"Safety box price",0.56999999999999995,null,null,"Default: UNICEF mean price (2020)",null,"Safety box price",0.56999999999999995,null,null,"Default: UNICEF mean price (2020)",null,"Safety box price",0.56999999999999995,null,null,"Default: UNICEF mean price (2020)",null,"Safety box price",0.56999999999999995,null,null,"Default: UNICEF mean price (2020)",null,"Safety box price",0.56999999999999995,null,null,"Default: UNICEF mean price (2020)"]
[null,null,"Safety box volume",100,null,null,"No. of doses per safety box/bag",null,"Safety box volume",100,null,null,"No. of doses per safety box/bag",null,"Safety box volume",100,null,null,"No. of doses per safety box/bag",null,"Safety box volume",100,null,null,"No. of doses per safety box/bag",null,"Safety box volume",100,null,null,"No. of doses per safety box/bag",null,"Safety box volume",100,null,null,"No. of doses per safety box/bag"]
[null,null,"Syringe price",0.04,null,null,"Default: UNICEF mean price (2020)",null,"Syringe price",0.04,null,null,"Default: UNICEF mean price (2020)",null,"Syringe price",0.04,null,null,"Default: UNICEF mean price (2020)",null,"Syringe price",0.04,null,null,"Default: UNICEF mean price (2020)",null,"Syringe price",0.04,null,null,"Default: UNICEF mean price (2020)",null,"Syringe price",0.04,null,null,"Default: UNICEF mean price (2020)"]
[]
[null,null,"PROGRAM COSTS",null,null,null,null,null,null,null,null,null,null,null,"PROGRAM COSTS",null,null,null,null,null,null,null,null,null,null,null,"PROGRAM COSTS"]
[]
[null,null,"Introduction costs include start-up costs such as expenditures related to microplanning, initial training, or communication. Typically, this includes expenditures only occurring in the first year to start up the HPV program (may be applicable to single-aged cohort and multi-aged cohort or just the single-aged cohort, depending on program) or switch vaccine products (applicable to single-aged cohort only). For each vaccine being compared, enter the amount budgeted for the one-time introduction costs. \n\nThe incremental cost of delivery per dose refers to all additional expenditures required to deliver vaccines, other than the one-time introduction costs and the direct cost of vaccines procurement and commodities. These include additional required expenditures related to staff, per diem, travel allowances, cold chain equipment, vehicles, transport and fuel, program management, ongoing training and capacity building, ongoing social mobilization and advocacy, disease surveillance and activities related to adverse events following immunization (AEFI), and waste management. Any system cost already incurred by the immunization system (shared costs) should be excluded. For example the cost of transporting HPV vaccine should not be included if this is part of the same transport used to deliver other vaccines. Only potential additional trips that may be needed should be included. Note that the incremental delivery costs might vary from one product to another based on product presentation, storage requirements, and ease of administration. Importantly, delivery costs differ based on the program approach (school-based, facility-based, outreach). Please enter costs specific to each approach used by the program or enter $0 for any approach not used. Inputs below are included as stylistic examples and should be updated to reflect the local program. You can find data on incremental cost per dose from a range of studies and countries through the Immunization Delivery Cost Catalogue (IDCC).",null,null,null,null,null,null,null,null,null,null,null,"Introduction costs include start-up costs, such as expenditures related to microplanning, initial training, or communication. Typically, this includes expenditures only occurring in the first year to start up the HPV program (may be applicable to single-aged cohort and multi-aged cohort or just the single-aged cohort, depending on program) or switch vaccine products (applicable to single-aged cohort only). For each vaccine being compared, enter the amount budgeted for the one-time introduction costs. \n\nThe incremental cost of delivery per dose refers to all additional expenditures required to deliver vaccines, other than the one-time introduction costs and the direct cost of vaccines procurement and commodities. These include additional required expenditures related to staff, per diem, travel allowances, cold chain equipment, vehicles, transport and fuel, program management, ongoing training and capacity building, ongoing social mobilization and advocacy, disease surveillance and activities related to adverse events following immunization (AEFI), and waste management. Any system cost already incurred by the immunization system (shared costs) should be excluded. For example the cost of transporting HPV vaccine should not be included if this is part of the same transport used to deliver other vaccines. Only potential additional trips that may be needed should be included. Note that the incremental delivery costs might vary from one product to another based on product presentation, storage requirements, and ease of administration. Importantly, delivery costs differ based on the program approach (school-based, facility-based, outreach). Please enter costs specific to each approach used by the program or enter $0 for any approach not used. Inputs below are included as stylistic examples and should be updated to reflect the local program. You can find data on incremental cost per dose from a range of studies and countries through the Immunization Delivery Cost Catalogue (IDCC).",null,null,null,null,null,null,null,null,null,null,null,"Introduction costs include start-up costs, such as expenditures related to microplanning, initial training, or communication. Typically, this includes expenditures only occurring in the first year to start up the HPV program (may be applicable to single-aged cohort and multi-aged cohort or just the single-aged cohort, depending on program) or switch vaccine products (applicable to single-aged cohort only). For each vaccine being compared, enter the amount budgeted for the one-time introduction costs. \n\nThe incremental cost of delivery per dose refers to all additional expenditures required to deliver vaccines, other than the one-time introduction costs and the direct cost of vaccines procurement and commodities. These include additional required expenditures related to staff, per diem, travel allowances, cold chain equipment, vehicles, transport and fuel, program management, ongoing training and capacity building, ongoing social mobilization and advocacy, disease surveillance and activities related to adverse events following immunization (AEFI), and waste management. Any system cost already incurred by the immunization system (shared costs) should be excluded. For example the cost of transporting HPV vaccine should not be included if this is part of the same transport used to deliver other vaccines. Only potential additional trips that may be needed should be included. Note that the incremental delivery costs might vary from one product to another based on product presentation, storage requirements, and ease of administration. Importantly, delivery costs differ based on the program approach (school-based, facility-based, outreach). Please enter costs specific to each approach used by the program or enter $0 for any approach not used. Inputs below are included as stylistic examples and should be updated to reflect the local program. You can find data on incremental cost per dose from a range of studies and countries through the Immunization Delivery Cost Catalogue (IDCC)."]
[]
[null,null,"One-time introduction cost or switch cost for single-aged cohort",50000,50000,50000,"Inputs should be updated to reflect local program costs using a lump sum or budget in first year, varied by cohorts, as applicable. If no MAC is used, enter $0 for that value.",null,"One-time introduction or switch for single-aged cohort",50000,50000,50000,"Inputs should be updated to reflect local program costs using a lump sum or budget in first year, varied by cohorts, as applicable. If no MAC is used, enter $0 for that value.",null,"One-time introduction or switch for single-aged cohort",50000,50000,50000,"Inputs should be updated to reflect local program costs using a lump sum or budget in first year, varied by cohorts, as applicable. If no MAC is used, enter $0 for that value.",null,"One-time introduction or switch for single-aged cohort",50000,50000,50000,"Inputs should be updated to reflect local program costs using a lump sum or budget in first year, varied by cohorts, as applicable. If no MAC is used, enter $0 for that value.",null,"One-time introduction or switch for single-aged cohort",50000,50000,50000,"Inputs should be updated to reflect local program costs using a lump sum or budget in first year, varied by cohorts, as applicable. If no MAC is used, enter $0 for that value.",null,"One-time introduction or switch for single-aged cohort",50000,50000,50000,"Inputs should be updated to reflect local program costs using a lump sum or budget in first year, varied by cohorts, as applicable. If no MAC is used, enter $0 for that value."]
[null,null,"One-time introduction cost for multi-aged cohort",100000,"N/A","N/A",null,null,"One-time introduction for multi-aged cohort",100000,"N/A","N/A",null,null,"One-time introduction for multi-aged cohort",100000,"N/A","N/A",null,null,"One-time introduction for multi-aged cohort",100000,"N/A","N/A",null,null,"One-time introduction for multi-aged cohort",100000,"N/A","N/A",null,null,"One-time introduction for multi-aged cohort",100000,"N/A","N/A"]
[null,null,"Incremental cost of delivery per dose: school ",1.5,1.5,1.5,"$ per dose delivered;\npotential source of data: the immunization delivery cost catalogue linked below, varied by delivery options: school, facility, outreach. Inputs should be updated to reflect local program costs.",null,"Incremental cost of delivery per dose: school ",1.5,1.5,1.5,"$ per dose delivered;\npotential source of data: the immunization delivery cost catalogue linked below, varied by delivery options: school, facility, outreach. Inputs should be updated to reflect local program costs.",null,"Incremental cost of delivery per dose: school ",1.5,1.5,1.5,"$ per dose delivered;\npotential source of data: the immunization delivery cost catalogue linked below, varied by delivery options: school, facility, outreach. Inputs should be updated to reflect local program costs.",null,"Incremental cost of delivery per dose: school ",1.5,1.5,1.5,"$ per dose delivered;\npotential source of data: the immunization delivery cost catalogue linked below, varied by delivery options: school, facility, outreach. Inputs should be updated to reflect local program costs.",null,"Incremental cost of delivery per dose: school ",1.5,1.5,1.5,"$ per dose delivered;\npotential source of data: the immunization delivery cost catalogue linked below, varied by delivery options: school, facility, outreach. Inputs should be updated to reflect local program costs.",null,"Incremental cost of delivery per dose: school ",1.5,1.5,1.5,"$ per dose delivered;\npotential source of data: the immunization delivery cost catalogue linked below, varied by delivery options: school, facility, outreach. Inputs should be updated to reflect local program costs."]
[null,null,"Incremental cost of delivery per dose: facility",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: facility",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: facility",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: facility",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: facility",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: facility",1.5,1.5,1.5]
[null,null,"Incremental cost of delivery per dose: outreach",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: outreach",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: outreach",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: outreach",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: outreach",1.5,1.5,1.5,null,null,"Incremental cost of delivery per dose: outreach",1.5,1.5,1.5]
[null,null,null,null,null,null,"IDCC",null,null,null,null,null,"IDCC",null,null,null,null,null,"IDCC",null,null,null,null,null,"IDCC",null,null,null,null,null,"IDCC",null,null,null,null,null,"IDCC"]

{"sheet":"Dashboard","index":3,"n_rows":1,"n_cols":1,"rows_kept":1,"cut":false,"hidden":true,"merged":[[0,0,0,35]]}
["HPV Vaccine Product Cost Calculator"]

{"sheet":"Sheet1","index":4,"n_rows":41,"n_cols":9,"rows_kept":41,"cut":false,"hidden":true,"merged":[[0,0,0,8],[1,1,1,7],[2,1,2,3],[6,0,7,0],[4,1,4,3],[5,1,5,3],[2,4,2,6],[4,4,4,6],[5,4,5,6],[3,1,3,3],[3,4,3,6]]}
["STEP 1: IMMUNIZATION PROGRAM"]
["Start year",2022]
["Sex","Grils ",null,null,"Boys ",null,null,"Not including women program"]
["Cohort choice","Single-aged cohort",null,null,"Single-aged cohort",null,null,null,"Single-aged cohort: 9 yrs; Multi-aged cohort: 10-14 yrs"]
["Target population",300000,null,null,100000,null,null,0,"children per year"]
["Annual population growth rate",0.03,null,null,0.02,null,null,0,"%"]
["Delivery options","School","Facility","Outreach","School","Facility","Outreach"]
[null,0.3,0.4,0.3,0.3,0.4,0.3,0]
["Expected coverage dose 1",0.75,0.3,0.75,0.75,0.3,0.75,0,"annual coverage"]
["Expected coverage dose 2",1,1,1,1,1,1,0,"annual coverage"]
["Expected coverage dose 3",0,0,0,0,0,0,0,"annual coverage"]
[]
[]
[]
["Cohort choice","Single-aged cohort (first year and follow-on years)",null,null,"9 years old","Enter information about age gorup"]
[null,"Multi-aged cohort (first year only)",null,null,"10-14 years old"]
["Target population for single-aged cohort or in year one",100,"--> year 1 * dose 1; year 2*dose2","--> subsequent years: 100+growth rate *dose 1",null,"dose 1 at jan 1st; dose 2 6 months"]
["Additional target population for multi-aged cohort in year 1",500,"--> year 1*dose 1; year 2*dose 2","--> subsequent years: 0",null,"dose 1 at jan 1st; dose 2 following january"]
[]
[]
[]
["Target population for single-aged cohort or in year one",null,null,100,null,null,"--> year 1 * dose 1; year 2*dose2","--> subsequent years: 100+growth rate *dose 1"]
["Additional target population for multi-aged cohort in year 1",null,null,500,null,null,"--> year 1*dose 1; year 2*dose 2","--> subsequent years: 0"]
[]
["Muti-aged cohort",2022,"Population coverage rate",0.9]
["Age",9,10,11,12,13,14]
["Population",100,100,100,100,100,100]
["Growth rate",0.3]
["Year"]
[1,{"$f":"B27*$D$25","v":90},90,90,90,90,90]
[2,{"$f":"B27*(1+B28)*$D$25","v":117},{"$f":"(C27*(1+$B$28)-C30)*$D$25","v":36},{"$f":"(D27*(1+$B$28)-D30)*$D$25","v":36},{"$f":"(E27*(1+$B$28)-E30)*$D$25","v":36},{"$f":"(F27*(1+$B$28)-F30)*$D$25","v":36},{"$f":"(G27*(1+$B$28)-G30)*$D$25","v":36}]
[3,{"$f":"B31*(1+$B$28)*$D$25","v":136.88999999999999},{"$f":"(C27*(1+$B$28)^2-C31-D31)*$D$25","v":87.300000000000026},{"$f":"(D27*(1+$B$28)^2-D31-E31)*$D$25","v":87.300000000000026},{"$f":"(E27*(1+$B$28)^2-E31-F31)*$D$25","v":87.300000000000026},{"$f":"(F27*(1+$B$28)^2-F31-G31)*$D$25","v":87.300000000000026},{"$f":"(G27*(1+$B$28)^2-G31-H31)*$D$25","v":119.70000000000003}]
[4]
[5]
[6]
[7]
[8]
[9]
[10]
[11]
[12]

{"sheet":"HPV results (girls 9-14)","index":5,"n_rows":83,"n_cols":43,"rows_kept":83,"cut":false,"hidden":false,"merged":[[71,37,71,38],[59,1,59,2],[59,8,59,9],[59,15,59,16],[59,23,59,24],[59,30,59,31],[59,37,59,38],[71,1,71,2],[71,8,71,9],[71,15,71,16],[71,23,71,24],[71,30,71,31],[58,37,58,38],[45,1,45,2],[45,8,45,9],[45,15,45,16],[45,23,45,24],[45,30,45,31],[45,37,45,38],[58,1,58,2],[58,8,58,9],[58,15,58,16],[58,23,58,24],[58,30,58,31],[19,23,19,24],[19,30,19,31],[33,37,33,38],[32,1,32,2],[32,8,32,9],[32,15,32,16],[32,23,32,24],[32,30,32,31],[32,37,32,38],[33,1,33,2],[33,8,33,9],[33,15,33,16],[33,23,33,24],[33,30,33,31],[19,37,19,38],[19,1,19,2],[6,37,6,38],[7,1,7,2],[7,8,7,9],[7,15,7,16],[7,23,7,24],[7,30,7,31],[19,8,19,9],[19,15,19,16],[0,1,0,16],[0,23,0,38],[4,1,4,2],[4,8,4,9],[4,15,4,16],[4,23,4,24],[4,30,4,31],[4,37,4,38],[7,37,7,38],[6,1,6,2],[6,8,6,9],[6,15,6,16],[6,23,6,24],[6,30,6,31]]}
[null,"RESULTS\nProgram for Girls 9-14 Years Old",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"RESULTS\nProgram for Girls 9-14 Years Old"]
[]
[null,"Conditional formatting  highlights 10-year cost cells from the least costly (green color) to the most costly (yellow color) option"]
[]
[null,{"$f":"'Model inputs'!D$117","v":"Cecolin, bivalent"},null,null,null,null,null,null,{"$f":"'Model inputs'!J$117","v":"Cecolin, bivalent"},null,null,null,null,null,null,{"$f":"'Model inputs'!P$117","v":"Cervarix, bivalent, 10"},null,null,null,null,null,null,null,{"$f":"'Model inputs'!V$117","v":"Gardasil-4, quadrivalent"},null,null,null,null,null,null,{"$f":"'Model inputs'!AB$117","v":"Gardasil-9, nonavalent"},null,null,null,null,null,null,{"$f":"'Model inputs'!AH$117","v":"Future vaccine to be defined by user (e.g. Zerun, bivalent)"}]
[]
[null,"IMMUNIZATION PROGRAM",null,"Helper Calculations (to be hidden)",null,null,null,null,"IMMUNIZATION PROGRAM",null,"Helper Calculations (to be hidden)",null,null,null,null,"IMMUNIZATION PROGRAM",null,"Helper Calculations (to be hidden)",null,null,null,null,null,"IMMUNIZATION PROGRAM",null,"Helper Calculations (to be hidden)",null,null,null,null,"IMMUNIZATION PROGRAM",null,"Helper Calculations (to be hidden)",null,null,null,null,"IMMUNIZATION PROGRAM",null,"Helper Calculations (to be hidden)"]
[null,"Number of doses delivered",null,"Single aged cohort","MAC",null,null,null,"Number of doses delivered",null,"Single aged cohort","MAC",null,null,null,"Number of doses delivered",null,"Single aged cohort","MAC",null,null,null,null,"Number of doses delivered",null,"Single aged cohort","MAC",null,null,null,"Number of doses delivered",null,"Single aged cohort","MAC",null,null,null,"Number of doses delivered",null,"Single aged cohort","MAC"]
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[null,"Conditional formatting  highlights 10-year cost cells from the least costly (green color) to the most costly (yellow color) option"]
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["Annual results"]
["Note that vertical axis scales are different by figure."]

{"sheet":"Vaccine options","index":11,"n_rows":21,"n_cols":7,"rows_kept":21,"cut":false,"hidden":true,"merged":[]}
[null,"Vaccine and presentation","Gavi Price per dose","Women price per dose","Doses in schedule","Wastage","Cold chain volume (cm3) per dose"]
[null,"Cecolin, bivalent",3,4.05,2,"Wastage for this presentation currently indicated at 5%, per Gavi's HPV Vaccine Profile (May 2021). User can input this value or use local estimates.",4.8]
[null,"Cervarix, bivalent",5.18,4.2,2,"Wastage for this presentation currently indicated at 10%, per Gavi's HPV Vaccine Profile (May 2021). User can input this value or use local estimates.",2.4]
[null,"Cervarix, bivalent, 10","unknown",3.8,2,"Please use best local estimate for wastage. No indicative wastage reported.",3.5]
[null,"Gardasil-4, quadrivalent",4.5,4.5999999999999996,2,"Wastage for this presentation currently indicated at 5%, per Gavi's HPV Vaccine Profile (May 2021).  User can input this value or use local estimates.",5]
[null,"Gardasil-9, nonavalent",6.9,5,2,"Wastage for this presentation currently indicated at 5%, per Gavi's HPV Vaccine Profile (May 2021).  User can input this value or use local estimates.",3.5]
[null,"Future vaccine to be defined by user (e.g. Zerun, bivalent)","unknown",4,2,"Please use best local estimate for wastage. No indicative wastage reported. User can input this value or use local estimates.",6]
[]
[]
[]
[null,"Gavi transition phase","Co-financing share","VIG grant","Operations Grant"]
["a. ","Initial self-financing phase",0.2,2.4,0.65]
[null,"Other transition phase",null,2.4]
["b. ","Preparatory transition phase",null,2.4,0.55000000000000004]
["c. ","Accelerated transition phase",null,2.4,0.45]
[null,"Not Gavi-eligible"]
[]
[]
[null,"Notes:"]
[null,"https://www.gavi.org/sites/default/files/support/Gavi_HPV_vaccine_profiles.pdf"]
[null,"The WHO recommends a 2-dose schedule for 9-14 year for HPV vaccines. A 3-dose schedule (0, 1–2, 6 months) should be used for all vaccinations initiated ≥15 years of age, including in those younger than 15 years known to be immunocompromised and/or HIV-infected."]

{"sheet":"DPP","index":12,"n_rows":44,"n_cols":18,"rows_kept":44,"cut":false,"hidden":true,"merged":[[41,1,41,13],[43,1,44,11],[35,1,35,12],[35,16,35,17],[36,1,36,12],[36,16,36,17],[37,1,37,12],[37,16,37,17],[32,3,32,7],[32,8,32,12],[33,3,33,7],[33,8,33,12],[34,3,34,7],[34,8,34,12],[29,3,29,7],[29,8,29,12],[30,3,30,7],[30,8,30,12],[31,3,31,7],[31,8,31,12],[26,3,26,7],[26,8,26,12],[27,3,27,7],[27,8,27,12],[28,3,28,7],[28,8,28,12],[23,3,23,7],[23,8,23,12],[24,3,24,7],[24,8,24,12],[25,3,25,7],[25,8,25,12],[20,3,20,7],[20,8,20,12],[21,3,21,7],[21,8,21,12],[22,3,22,7],[22,8,22,12],[17,3,17,7],[17,8,17,12],[18,3,18,7],[18,8,18,12],[19,3,19,7],[19,8,19,12],[14,3,14,7],[14,8,14,12],[15,3,15,7],[15,8,15,12],[16,3,16,7],[16,8,16,12],[11,3,11,7],[11,8,11,12],[12,3,12,7],[12,8,12,12],[13,3,13,7],[13,8,13,12],[8,2,8,7],[8,8,8,12],[9,3,9,7],[9,8,9,12],[10,3,10,7],[10,8,10,12],[1,1,1,12],[2,16,4,19],[3,1,4,12],[6,2,6,12],[7,2,7,7],[7,8,7,12]]}
[]
[null,"ON THE                              MENU",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"OTHER PREQUALIFIED VACCINES NOT ON THE GAVI MENU"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"The vaccines listed below are not offered by Gavi and are not listed in the country application portal.   The vaccines listed in this section are provided for information only.   The DPPs will be updated on a fixed schedule (approximately every 6 months) or with more frequency if required."]
[null,"The vaccines listed below are currently offered by Gavi and listed in the country application portal.   \n"]
[]
[]
[null,"Vaccine group1 ","HPV",null,null,null,null,null,null,null,null,null,null,null,null,null,"Vaccine group1 ","HPV"]
[null,"Vaccine type1 ","HPV Bivalent Recombinant virus like particle vaccine",null,null,null,null,null,"HPV Quadrivalent Recombinant virus like particle vaccine",null,null,null,null,null,null,null,"Vaccine type1 ","HPV Bivalent"]
[null,"Serotypes1","HPV types 16 and 18",null,null,null,null,null,"HPV types 6, 11, 16 and 18 ",null,null,null,null,null,null,null,"Serotypes1","16, 18"]
[null,"Presentation (doses per container, primary container type, pharmaceutical form)1","HPV2, 1 dose/vial, liquid","HPV2, 2 doses/vial, liquid",null,null,null,null,"HPV4, 1 dose/vial, liquid",null,null,null,null,null,null,null,"Presentation (doses per container, primary container type, pharmaceutical form)1","1 dose vial, liquid"]
[null,"Product availability 20222","TBD","limited supply",null,null,null,null,"limited supply",null,null,null,null,null,null,null,"Product availability 20212","n/a"]
[null,"Routine and/or campaign","routine","routine",null,null,null,null,"routine",null,null,null,null,null,null,null,"Routine and/or campaign","n/a"]
[null,"WHO recommended vaccine schedule3","For girls  aged 9-14 years:2-dose schedule (0.5 mL at 0 and 6 months)","For girls aged 9–14 years: \n2-dose schedule (0.5 mL at 0 and 6 months), with exceptions for special populations",null,null,null,null,"For girls and boys aged 9-13 years: 2-dose schedule (0.5 mL at 0 and at least 6 months), with exceptions for special populations",null,null,null,null,null,null,null,null,"2-dose schedule (0.5 mL at 0 and 6 months)"]
[null,"2022 price per dose (USD)4","$3.00 6",5.18,null,null,null,null,4.5,null,null,null,null,null,null,null,"2021 price per dose (USD)4","n/a"]
[null,"Doses per fully immunised person",2,2,null,null,null,null,2,null,null,null,null,null,null,null,"Doses per fully immunised person",2]
[null,"2022 price per fully immunised person (USD) 4***",6,{"$f":"D14*2","v":10.36},null,null,null,null,{"$f":"I14*2","v":9},null,null,null,null,null,null,null,"2021 price per fully immunised person (USD) 4","n/a"]
[null,"Indicative wastage rate 5",0.05,9.90990990990991E-2,null,null,null,null,4.7619047619047603E-2,null,null,null,null,null,null,null,"Indicative wastage rate5","n/a"]
[null,"Country specific actual wastage rate (input required)4",0.05,0.1,null,null,null,null,0.05,null,null,null,null,null,null,null,"Country specific actual wastage rate (input required)4","n/a"]
[null,"2022 wastage adjusted price per fully immunised person (USD)4",{"$f":"C16/(1-C18)","v":6.3157894736842106},{"$f":"D16/(1-D18)","v":11.511111111111111},null,null,null,null,{"$f":"I16/(1-I18)","v":9.4736842105263168},null,null,null,null,null,null,null,"2021 wastage adjusted price per fully immunised person (USD)4","n/a"]
[null,"Manufacturer1","Xiamen Innovax Biotech Co., Ltd.","GlaxoSmithKline Biologicals S.A.",null,null,null,null,"Merck Sharp & Dohme Corp.",null,null,null,null,null,null,null,null,"GlaxoSmithKline Biologicals S.A."]
[null,"Vaccine trade name1","Cecolin®","CervarixTM",null,null,null,null,"Gardasil®",null,null,null,null,null,null,null,null,"Cervarix"]
[null,"Country of manufacture1","China","Belgium",null,null,null,null,"USA",null,null,null,null,null,null,null,"Country of manufacture1","Belgium"]
[null,"National regulatory agency1","NMPA(China)","FAMHP (Belgium)",null,null,null,null,"EMA (European Medicines Agency) ",null,null,null,null,null,null,null,null,"FAMHP (Belgium)"]
[null,"WHO PQ-date1","Prequalification expected in 2021","2009-07-08",null,null,null,null,"2009-05-20",null,null,null,null,null,null,null,"WHO PQ-date1","2009-07-08"]
[null,"Administration1","intramuscular","intramuscular",null,null,null,null,"intramuscular",null,null,null,null,null,null,null,null,"intramuscular"]
[null,"Secondary packaging1"," carton of 10 vials","carton of 1 vial\n carton of 10 vials\n carton of 100 vials*",null,null,null,null,"carton of 1 vial\ncarton of 10 vials*",null,null,null,null,null,null,null,"Secondary packaging1","carton of 1 vial\n carton of 10 vials\n carton of 100 vials"]
[null,"Shelf-life1","24 months  at 2 - 8 °C ","60 months at 2 - 8 °C ",null,null,null,null,"36 months at 2 - 8 °C ",null,null,null,null,null,null,null,"Shelf-life1","48 months at 2 - 8 °C "]
[null,"Cold chain volume per dose (cm3)1"," carton of 10 vials : 14.6 cm3","carton of 1 vial : 28.8 cm3\n carton of 10 vials : 5.7 cm3\n carton of 100 vials : 4.8 cm3*",null,null,null,null,"carton of 1 vial: 75 cm3\n carton of 10 vials: 15 cm3*",null,null,null,null,null,null,null,"Cold chain volume per dose (cm3)1","carton of 1 vial : 57.7 cm3\n carton of 10 vials : 11.5 cm3\n carton of 100 vials : 9.7 cm3"]
[null,"Vaccine vial monitor type1","Type 30","Type 30",null,null,null,null,"Type 30",null,null,null,null,null,null,null,"Vaccine vial monitor type1","Type 30"]
[null,"Handling open vials1","n/a","WHO recommends that opened vials of  this vaccine should be discarded 6 hours after opening or at the end of the immunization session, whichever comes first.**",null,null,null,null,"n/a",null,null,null,null,null,null,null,"Handling open vials1","n/a"]
[null,"Controlled Temperature Chain (CTC)¹","n/a","n/a",null,null,null,null,"Data from stability studies demonstrate that the vaccine components are stable for 72 hours when stored at temperatures from 8°C to 42°C. At the end of this period Gardasil should be used or discarded. These data are intended to guide healthcare professionals in case of temporary temperature excursion only. A CTC is initiated immediately prior to administration, provided that the vaccine has not reached its expiry date and the vaccine vial monitor is still valid. ",null,null,null,null,null,null,null,"Controlled Temperature Chain (CTC)¹","n/a"]
[null,"WHO PQ link1","TBD","https://extranet.who.int/pqweb/content/cervarix-0",null,null,null,null,"https://extranet.who.int/pqweb/content/gardasil",null,null,null,null,null,null,null,"WHO PQ link1","https://extranet.who.int/gavi/PQ_Web/PreviewVaccine.aspx?nav=0&ID=179"]
[null,"Remarks WHO1","n/a","July 2014: Product Insert updated to include a two dose schedule for recipients aged 9-13 years\n\nA two dose preservative-free liquid presentation is  a novel presentation for UN supported EPI programmes. Therefore its use requires specific training for immunization staff and it will undergo formal post-introduction monitoring.** ",null,null,null,null," \nJune 2016: Product Insert updated to include indication for ECTC use \nSept 2014: Product Insert updated to include \nalternative two dose schedule for recipients aged 9-13 years.",null,null,null,null,null,null,null,"Remarks WHO1","July 2014: Product Insert updated to include a two dose schedule for recipients aged 9-14 years "]
[null,"Notes","n/a","n/a",null,null,null,null,"n/a",null,null,null,null,null,null,null,"Notes","n/a"]
[null,"Vaccine price commitments","n/a","Please refer to https://www.gavi.org/sites/default/files/document/supply-procurement/vaccine-price-commitments-from-manufacturers.pdf",null,null,null,null,"Please refer to https://www.gavi.org/sites/default/files/document/supply-procurement/vaccine-price-commitments-from-manufacturers.pdf",null,null,null,null,null,null,null,"Vaccine price commitments","n/a"]
[null,"1 Source: WHO PQ webpage: WHO updates these webpages as new information on products becomes available. Please refer to these pages (WHO PQ link) for the most up-to-date information. For presentations not yet WHO prequalified, data is based on discussions with manufacturers and partners in 2021.",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"1 Source: WHO PQ webpage: WHO updates these webpages as new information becomes available. \nPlease refer for these pages for the most up-to-date information."]
[null,"2 Source: UNICEF PRODUCT MENU FOR VACCINES SUPPLIED BY UNICEF FOR GAVI, THE VACCINE ALLIANCE (https://www.unicef.org/supply/media/8661/file/Gavi-product-menu-July-2021.pdf)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"2 Source: UNICEF PRODUCT MENU FOR VACCINES SUPPLIED BY UNICEF FOR GAVI, THE VACCINE ALLIANCE (https://www.unicef.org/supply/media/8661/file/Gavi-product-menu-July-2021.pdf)"]
[null,"3 Source: WHO position paper: http://www.who.int/immunization/documents/positionpapers/en/",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"3 Source: WHO position paper: http://www.who.int/immunization/documents/positionpapers/en/"]
[null,"4 Source: Gavi Secretariat, see definitions tab for details ",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"4 Source: Gavi Secretariat, see definitions tab for details "]
[null,"5 Source: Review of WHO vaccine wastage rate tool, 2021",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"5 Source: Review of WHO vaccine wastage rate tool, 2021"]
[null,"6 The price of this presentation is an indicative estimation for budgeting purposes. It will be updated once a public information is available."]
[null,"* This secondary packaging is procured for Gavi countries by UNICEF. For this presentation, the secondary packaging without an asterisk in grey font is not procured on behalf of Gavi."]
[null,"**For more information see: http://www.who.int/immunization_standards/vaccine_quality/cervarix_pqnote_2dose_2013/en/"]
[null,"***Estimated assuming 2 doses for fully immunized child. Special populations will need 3 doses. See WHO position paper on HPV vaccines,\n 2014 [http://www.who.int/entity/wer/2014/wer8943.pdf?ua=1]"]